Health Condition 1: P288- Other specified respiratory conditions of newborn
Conditions
Interventions
Intervention1: Nebulization with salbutamol: Recruited neonates will receive one dose of nebulization with 4 mL of Salbutamol Respirator solution (2.5 mg/2.5 mL in 0.9% saline solution) with a jet typ
Sponsors
All India Institute of Medical Sciences Rishikesh
Sriparna Basu
Eligibility
Inclusion criteria
Inclusion criteria: Consecutively delivered inborn neonates and outborn neonates admitted within 6 hours of life of gestational age =34 weeks, developing respiratory distress (tachypnea with or without nasal flaring, intercostal/subcostal/suprasternal retractions, grunting, crackles, diminished breath sounds on auscultation, cyanosis) soon after birth persisting for at least 6 hours, diagnosed as transient tachypnea of newborn (TTN) based on the modified criteria of Rawlings and Smith.
Exclusion criteria
Exclusion criteria: Neonates with: 1. Perinatal asphyxia 2. Presence of maternal risk factors for sepsis/chorioamnionitis 3. Major congenital and/or chromosomal anomaly 4. Lack of parental consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of tachypnea defined as respiratory rate 60 per minuteTimepoint: At 96 hours or before when tachypnea resolves | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The need and duration of oxygen supplementation to maintain a target SpO2 of 90-94%. 2. The need and duration of respiratory support. 3. The need and duration of mechanical ventilation. 4. Clinical assessment of respiratory distress as quantified by Downes score. 5. The time (hours) of initiation and establishment of breastfeeding/oral feeding. 6. The duration of hospital stay. 7. Adverse events while using nebulized salbutamol such as tachycardia, arrhythmia, electrolyte disturbances etc. 8. Final outcome. Timepoint: At discharge | — |
Countries
India
Contacts
Public ContactSriparna Basu
All India Institute of Medical Sciences, Rishikesh
Outcome results
None listed