Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Intermittent theta burst stimulation(iTBS), active: For medial prefrontal cortex stimulation,the deep iTBS coil will be placed over the site of stimulation ,coil position would be deter
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization, 1993). 2.Aged between 18- 60 years, right-handed individuals of either sex. 3.An illness of duration more than 2 years & on stable dose of antipsychotics. 4.Patients with significant deficit syndrome [Based upon PANSS, one can assess deficit syndrome by using a formula [(blunted affect + emotional withdrawal) - (anxiety+ guilt feelings + depressive mood + hostility)]. A cut-off point of more than â?? 2 will be used to categorize the deficit group[Gard et al.,2006]. This method is also known as Proxy deficit syndrome (PDS) criteria] 5.Scale for Assessment of Negative Symptoms (SANS) score more than 20. 6.Calgary Depression Scale for Schizophrenia (CDSS) score less than 7. 7.Patients giving written informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of comorbid neurological or other psychiatric disorder(s). 2.Patients with comorbid substance dependence in the last 6 months, except nicotine and caffeine. 3.Subjects who have received ECT/ any other neuromodulation in the past one months. 4.Patients with contraindications to iTBS like pacemakers, metallic implants etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in scores of PANSS,SANS,TEPS,RSAS,SCS,CGI-SCH.Timepoint: Baseline, 1 week, 3 week | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes on fNIRS in specified brain areasTimepoint: Baseline, 1 week | — |
Countries
India
Contacts
Public ContactDr Umesh S
Central Institute of Psychiatry
Outcome results
None listed