Comparison of effects of the submucosal infiltration of Tramadol, Dexamethasone, and Articaine on anaesthetic efficacy of Inferior Alveolar nerve block (IANB) with Articaine in patients with Symptomatic Irreversible Pulpitis

"COMPARITIVE EVALUATION OF EFFECTS OF SUBMUCOSAL INFILTRATION OF TRAMADOL, DEXAMETHASONE AND 4% ARTICAINE ON ANASTHETIC EFFICACY OF INFERIOR ALVEOLAR NERVE BLOCK WITH 4% ARTICAINE IN PATIENTS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS- A RANDOMISED CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/05/052331

Enrollment

Registered

2023-05-08

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Tramadol Dexamethasone Articaine : Tramadol i.v. 100 mg/2 mL Dexamethasone i.v. 8 mg /2 mL Articaine 2 mL, 4% articaine submucosal infiltration.The duration will be 5 minutes. C

Eligibility

Inclusion criteria

Inclusion criteria: Patients between 18-65 years of age. Patients with no systemic diseases or medical conditions. Teeth responding long-term to cold test (that is long-lasting, continued stimulation of the pain after the cold stimuli is removed). Mandibular first and/or second teeth with SIP with a radiographically normal periapical region and no percussion pain. Preoperative pain score ranging from moderate to severe (55â??170 mm) on the Heftâ??Parker Visual Analogue Scale (HP VAS, 0â??170 mm).1 Ability to understand the informed consent form and pain recording scales used within the study.

Exclusion criteria

Exclusion criteria: Pregnant or breastfeeding patients (pregnant or lactating women and women regularly using oral contraceptives). Patients with allergy to articaine, dexamethasone or tramadol. Allergies, sensitivity or side effects related to any opioid or nonopioid drugs including aspirin or NSAIDs. Periodontal disease, pulp necrosis, calcified root canals, root resorption, open apex or unrestorable teeth. Patients who had used analgesic or anti-inflammatory drugs within 24 hours before the treatment.

Design outcomes

Primary

Measure	Time frame
efficacy of the additional pre-operative submucosal use of Articaine is more as compared to Tramadol, and Dexamethasone in addition to Inferior Alveolar Nerve Block(IANB). Duration is more in cases where dexamethasone is usedTimepoint: 4 weeks	—

Secondary

Measure	Time frame
Duration of anaesthesia gets prolonged when dexamethasone is usedTimepoint: 4 months	—

Countries

India

Contacts

Public ContactDr Amandeep kaur sachdeva

Surendera Dental College and Research Institue, Sri Ganganagar

drneetujindal@gmail.com9929854146

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026