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Comparison between nebulization by ketamine versus magnesium sulphate on incidence of post operative sore throat after endotracheal intubation

A randomized comparative study of effect of preoperative nebulization with ketamine versus magnesium sulphate on incidence of postoperative sore throat in patient undergoing surgery in general anaesthesia with endotracheal intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052303
Enrollment
210
Registered
2023-05-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Preoperative Nebulization: Preoperative Nebulization with Ketamine versus Magnesium Sulphate Intervention2: Preoperative nebulization: Preoperative nebulization with 250mg MgSo4 through

Sponsors

Ramandeep Kaur
Lead Sponsor
SUBHARTI MEDICAL COLLEGE
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 1-2 Supine position under General Anaesthesia Informed Consent

Exclusion criteria

Exclusion criteria: Patients with Physical Status of ASA Grade 3 or greater Preoperative sore throat Upper airway infection Duration of surgery >120 mins Oral surgeries Pregnant women Severe cardiorespiratory, hepatic, renal, neurological or endocrinal disease Patients with known hypersenstivity or drug allergies Obese patients weight >80kg Epileptic patient Nausea, retching or vomiting within 48hr before surgery History of motion sickness Patients who refuse to participate in the study

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the incidence of postoperative sore throat after magnesium sulphate and ketamine nebulization and normal saline nebulization. To evaluate and compare effect on hemodynamics of the patient after magnesium sulphate and ketamine nebulization and normal saline nebulization.Timepoint: 0 hour, 2 hours, 6 hours, 8 hours, 12hours, 24hours—

Secondary

MeasureTime frame
To evaluate side effect (if any) of ketamine and magnesium sulphate. To evaluate patients satisfaction with nebulization done by ketamine and magnesium sulphate.Timepoint: 3mins, 5mins, 10mins, 15mins, 20mins, 25mins, 30mins, 40mins, 50mins, 60mins—

Countries

India

Contacts

Public ContactRamandeep Kaur

subharti medical college and hospital

28bhawana75@gmail.com8449114984

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026