Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
None listed
Sponsors
HBT Medical College Dr RN Cooper Hospital Mumbai
Eligibility
Inclusion criteria
Inclusion criteria: Heart rate variability to assess autonomic functions will be studied in 65 consecutive patients presenting with idiopathic PD according to the MDS-PD criteria, age 30-60 years visiting neurology outpatient department of Municipal General Hospital. Prior approval of ethics committee will be taken and informed consent obtained from the patients. Patients without any concomitant cardiovascular disease as confirmed by physical examination and normal 12-lead ECG will be included in the study.
Exclusion criteria
Exclusion criteria: Patients suspected of atypical/ secondary Parkinsonism as per MDS-PD criteria will be excluded from the study. Patients with dementia (as assessed by Mini Mental State Scale) that would affect their ability to provide consent and reliable self report will be excluded from the study. Patients with other medical conditions or co-morbidities or drugs as assessed by history, clinical examination and previous investigations known to affect autonomic nervous system or heart rate variability will be excluded from the study. 1. Atypical/ secondary Parkinsonism 2. Significant neurological disease such as stroke or epilepsy 3. Diabetes mellitus 4. Coronary artery disease / heart failure / myocardial infarction 4. Dyslipidemia, Hypertension 5. History of smoking/ alcohol intake 6. Broncho- pulmonary disease, dypnea. 7. Amyloidosis/ neuropathy 8.Patients who had medication known to influence autonomic system and biological rhythms will also be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -To evaluate autonomic dysfunction in Parkinsons disease patients by linear and non-linear indices of short-term heart rate variability. Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| - To evaluate the predictive value of heart rate variability for autonomic dysfunction in Parkinsons disease by using Receiver operated curve (ROC).Timepoint: 3 years;To co-relate heart rate variability parameters with autonomic symptoms, duration and severity of disease, levodopa/levodopa equivalent dose in Parkinsons disease patients.Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr Mukta P Bidikar
NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital
Outcome results
None listed