Health Condition 1: H578- Other specified disorders of eye and adnexa
Conditions
Interventions
None listed
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Either Sex Age equal or greater the age of 18 Yrs. Patient willing to give consent for the study No corneal scarring Average corneal power is equal 49.00 Diopter Higher order aberration is equal 1.50μm
Exclusion criteria
Exclusion criteria: Patients under the age of 18 Yrs. Patients not willing for investigation, tear fluids and blood sampling History of previous ocular disease or surgery Corneal scarring or any corneal pathology other than keratoconus Keratoconus secondary to other causes i.e. Trauma, Surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Initial analyses indicate that keratoconus may be associated with the differential expression of several proteins. Although many differences have been identified that distinguish the KC cornea from the normal cornea, it has not been possible to trace these changes back to primary causes or identify the triggers that precipitate the cascade of events leading to the clinical picture of KC. Further testing is needed to determine any causal relationship or correlation with the etiology of this condition. Our study will be instrumental in decoding the role of tear proteomics in KC amongst group patients. The identified proteins will be likely to have a significant role in the disease and make it possible to understand the events occurring in tears that intervene in the pathophysiology of KC.Timepoint: 3-Years | — |
Secondary
| Measure | Time frame |
|---|---|
| NA Timepoint: 0.00 | — |
Countries
India
Contacts
Public ContactDr Ramkishor Sah
Dr. R P Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
Outcome results
None listed