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Nebulization with 3% hypertonic saline vs adrenaline in Acute bronchiolitis

Study to evaluate the efficacy and safety of nebulized 3% hypertonic saline vs nebulized adrenaline in Acute bronchiolitis : A Randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052255
Enrollment
132
Registered
2023-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J219- Acute bronchiolitis, unspecified

Interventions

Intervention1: 3% hypertonic saline: Nebulization with 3ml 3% hypertonic saline stat then 1hly interval for 2times f/b- 2hlry 3times - f/b 4hrly for 3 days Control Intervention1: Adrenaline: Nebulizat

Sponsors

Dr. Anupama Singh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children with a chronological age of 2 months to 24 months, a clinical diagnosis of bronchiolitis and their initial Wang respiratory score will be 3 or higher will be included in study

Exclusion criteria

Exclusion criteria: 1.Patients not giving consent. 2.Children with prior illness with wheezing will be excluded. 3.Children with prior use of bronchodilators. 4.Premature infants ( 5.Children with congenital heart disease. 6.Children with chronic lung disease 7.Severe bronchiolitis (either wang score >9 or baseline oxygen saturation

Design outcomes

Primary

MeasureTime frame
1)Efficacy of 3% hypertonic saline vs Nebulised Adrenaline 2)Safety of 3% hypertonic saline vs Nebulised AdrenalineTimepoint: Monitoring parameters for improvement or worsening of the condition will be measured and recorded on admission and then at 24 hours,48 hours and 72 hours of admission using the clinical score described by Wang et al.

Secondary

MeasureTime frame
1) Changes in clinical scoring 2)Duration of hospitalizationTimepoint: 1) at the time of admission then at 24 hours,48 hours and then at 72 hours of admission 2) Number of days child was admitted

Countries

India

Contacts

Public ContactDr Mani Kant Kumar

Narayan medical college and hospital

manikant7@yahoo.com9162095353

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026