Health Condition 1: P84- Other problems with newborn
Conditions
Interventions
Intervention1: Population Epinephrine (P epi): Nebulization with L epinephrine 15 minutes after extubation
Control Intervention1: Control group (PStd): No nebulization with epinephrine after extubatio
Sponsors
Department of Neonatology Lok Nayak hospital Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All the neonates who at the time of extubation have been ventilated for more than 2 completed days.
Exclusion criteria
Exclusion criteria: 1.Vocal cord anomalies and another anatomic abnormality of the upper airways before intubation as noticed and recorded during intubation. 2.Seconde extubation. 3. Previous use of epinephrine in neonates during hospitalization or prior to extubation. 4. Silverman Anderson score 0/10 immediately after extubation with no evidence of hypoxemia on pulse oximeter in room air over 15 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the role of epinephrine nebulization in addition to standard care in successfully preventing extubation failure in term and preterm neonates.Timepoint: 48 hours after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the advantage of using post extubation epinephrine nebulization in term and preterm neonates with regard to; duration of post-extubation noninvasive respiratory support, hospital stay, time to reintubation. To determine occurrence of death, laryngeal edema, VAP, sepsis, any side effects of nebulized epinephrine.Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Arunima Bhardwaj
Department of Neonatology, M.A.M.C. Delhi.New Delhi
Outcome results
None listed