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Comparative study of Hyperbaric Levobupivacaine (0.5%) with Dexmedetomidine given intrathecally versus Hyperbaric Levobupivacaine (0.5%) with Dexmedetomidine given intravenously in patients undergoing lower abdominal and lower limb surgeries under spinal anesthesia

Comparative study of Hyperbaric Levobupivacaine (0.5%) with Intrathecal Dexmedetomidine and Hyperbaric Levobupivacaine (0.5%) with Intravenous Dexmedetomidine in patients undergoing lower abdominal and lower limb surgeries under spinal anesthesia- A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052215
Enrollment
90
Registered
2023-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INTRATHECAL HYPERBARIC LEVOBUPIVACIANE (0.5%) WITH INTRAVENOUS DEXMEDETOMIDINE (0.5ug/kg): Patients will receive Intravenous Dexmedetomidine (0.5ug/kg) in 100 ml NS over 10 mins + 3 m

Sponsors

ANAND S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -American Society of Anesthesiologists (ASA) grade I-II. -Age group between 18-65 years. -Scheduled for Lower abdominal surgeries. -Both Elective and Emergency procedures.

Exclusion criteria

Exclusion criteria: -Patient refusal -Patients using alpha 2â??adrenergic receptors antagonists, calcium channel blockers, angiotensin â?? converting enzyme inhibitors -History of allergy to study drugs -Post spinal surgeries, Spinal Deformities -Pregnancy -Coagulopathy -Dysrhythmia -Major Hepatic, Renal and Cardiovascular Dysfunction -BMI >35 -Height -Heart Rate

Design outcomes

Primary

MeasureTime frame
-To compare onset and duration of sensory blockade. -To compare onset and duration of motor blockade. Timepoint: Patient will be put in supine position soon after Sub arachnoid block motor and sensory blockade will assessed as baseline from the time of administration of test drug and each minute upto 15 minutes followed by every 15 minutes once upto 120 minutes—

Secondary

MeasureTime frame
To assess duration of analgesia.Timepoint: Duraion of analgesia will be noted (onset of sensory block to onset of pain postoperatively- VAS more than 3 ;To assess Hemodynamic changes and side effects if anyTimepoint: Patientâ??s HR, NIBP, SPO2 will be monitored at 3 min interval up to 15 minutes after that every 5 mins up to 60 mins after that every 10 mins until end of the procedure.;To assess sedation scoreTimepoint: Ramsay Sedation score is monitored every 15 mins from the time of IV infusion for 2hrs intraoperatively and immediately at postoperative.—

Countries

India

Contacts

Public ContactDr Anand S

Chettinad Academy of Research and Education

dranandmurugan@gmail.com9444486183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026