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Efficacy of lignocaine with dexmedetomidine in comparison to lignocaine with adrenaline in mandibular third molar surgery: A randomised clincial trial

Efficacy of 2% lignocaine combined with dexmedetomidine in comparison with 2% lignocaine with 1:80,000 adrenaline in mandibular third molar surgery : A randomised clinical trial

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052189
Enrollment
50
Registered
2023-05-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Dexmedetomidine combined with lignocaine: 5mcg/ml, that is 12.5 mcg or 0.25 ml of dexmedetomidine will be combined with 3 ml of 2% lignocaine hydrochloride as a local anesthetic. Route

Sponsors

Chhattisgarh Dental College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I (Healthy patients) 2. Patients with Pederson’s difficulty index score 5-6 (moderately difficult) 3. Patients willing for third molar extraction and participating in the study

Exclusion criteria

Exclusion criteria: 1. Impacted third molars associated with acute infections or pathologies. 2. Pregnant and lactating females and patients on oral contraceptives. 3. Medically compromised patients (hypertension, bradycardia, hypotension, sinus disorder, liver disorders, renal impairment and uncontrolled diabetes) 4. Tobacco chewers and smokers. 5. Patients allergic to lignocaine with dexmedetomidine, lignocaine, and adrenaline

Design outcomes

Primary

MeasureTime frame
To study the efficacy of dexmedetomidine combined with 2% lignocaine on: Onset of Anesthesia Duration of Anesthesia Pain Edema Mouth OpeningTimepoint: 24 hours, 72 hours, 120 hours, 168 hours

Secondary

MeasureTime frame
To compare the efficacy of 2% lignocaine combined with dexmedetomidine to 2% lignocaine with 1:80,000 adrenalineTimepoint: 24 hours, 72 hours, 120 hours, 168 hours

Countries

India

Contacts

Public ContactRajdeep Singh

Chhattisgarh Dental College and Research Institute

rajdeepsinghdurg@gmail.com7587101121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026