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To compare number of healthy household contacts aged between 6 to 18 years developing TB disease with tor without TB prophylactic therapy.

Effectiveness of Tuberculosis Preventive Therapy on Healthy Household Contact- An Open Label Randomised Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/052146
Enrollment
80
Registered
2023-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Healthy contacts receiving preventive therapy: Healthy contacts receiving 6 months of isoniazid @10mg/kg/dose as preventive therapy Control Intervention1: Healthy Household Contacts not

Sponsors

Dr Poulomi Roy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children 6-18 years of age who are healthy household contacts of people with bacteriologically confirmed pulmonary TB

Exclusion criteria

Exclusion criteria: Children in contact with adults having Multidrug resistant TB or Extensively drug resistant TB

Design outcomes

Primary

MeasureTime frame
We will compare the proportion of healthy household contacts aged 6-18 years developing TB over 9 months after receiving 6 months INH vs no TB preventive therapyTimepoint: Baseline, 2 weeks, 2 months, 4 months, 6 months and 9 months—

Secondary

MeasureTime frame
we will compare the proportion of healthy household contacts developing TBITimepoint: 9 MONTHS—

Countries

India

Contacts

Public ContactPoulomi Roy

Eras Lucknow Medical College and Hospital

geetikasri@gmail.com9721066555

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026