Health Condition 1: X- New Technology
Conditions
Interventions
Intervention1: Platelet Rich plasma (PRP): Autologous PRP will be prepared in the department of blood bank. PRP injection will be planned in the proliferative phase of the menstrual cycle preceding th
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Patients with thin endometrium ( 1. on the day of ovulation trigger in previous fresh Embryo transfer (ET) cycle, OR 2. at the end of estrogen priming in previous frozen embryo transfer (FET) cycle, OR 3. on day of ovulation trigger in previous IUI cycles, OR. 4. on baseline scans (mock cycles), despite standard estrogen supplementation (6-12 mg/day) for 12 days 5. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Hematologic disorders, hemoglobin level of 2. Auto-immune disease 3. Evidence of genital tuberculosis 4. Any factor that compromises implantation, other than endometrium,e.g. Hydrosalpinx (unclipped), Adenomyosis 5. Refusal to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Endometrial thickness and pattern beyond 7mm Mean increase in endometrial thickness Timepoint: Pre PRP injection, 2 weeks after PRP, 3 weeks after PRP | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in endometrial vascularity on the day of trigger in IVF cycle by Applebaum criteria Implantation rate Clinical Pregnancy rate Ongoing pregnancy rate Miscarriage rateTimepoint: Baseline pre PRP, 2 weeks, 3 weeks | — |
Countries
India
Contacts
Public ContactDr Juhi Bharti
All India Institute of Medical Sciences New Delhi
Outcome results
None listed