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To compare the effectiveness of carbetocin and oxytocin in controlling blood loss when admisinstered during vaginal delivery

A randomized control trial to evaluate the efficacy of carbetocin in comparison with oxytocin in active management of third stage of labour

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/052133
Enrollment
220
Registered
2023-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage

Interventions

Intervention1: Carbetocin: Group A patients will receive injection carbetocin 100 mcg intramuscularly on anterolateral aspect of thigh within 1 minute of delivery of the baby Control Intervention1: Ox

Sponsors

Pondicherry Institute Of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Pregnant women above the age of 21 years 2) Singleton term pregnancies ( >37 weeks of gestational age) 3) Live fetus- vertex presentation

Exclusion criteria

Exclusion criteria: 1) Traumatic PPH 2) Placenta previa 3) Abruptio placenta 4) Severe pre-eclampsia 5) Severe anemia 6) Gestational thrombocytopenia, TTP, ITP 7) Sensitivity to oxytocin or carbetocin 8) Serious cardiovascular disorders, hepatic, renal disorders, epilepsy 9) Multiple pregnancies 10) Chorioamnionitis 11) Polyhydraminos 12) Macrosomia 13) History of previous postpartum hemorrhage

Design outcomes

Primary

MeasureTime frame
To measure the effect of intramuscular carbetocin in reducing the blood loss during vaginal delivery as compared to intramuscular oxytocin.Timepoint: 24 hours—

Secondary

MeasureTime frame
To compare the following parameters between the groups receiving intramuscular carbetocin and intramuscular oxytocin 1. Duration of third stage of labour 2. Need of additional uterotonics 3. Side effects 4. Post-natal hemoglobin Timepoint: 24 hours—

Countries

India

Contacts

Public ContactLal Bahadur Palo

Pondicherry Institute Of Medical Sciences

palolalbahadur@gmail.com9894744050

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026