It is a study to compare ketofol(1:1) and propafol by measuring intracranial pressure and Intraocular pressure

Comparison of changes in Intracranial and Intraocular pressure with Ketofol (1:1) versus Propafol as induction Agents in patients undergoing general surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/04/052128

Enrollment

Registered

2023-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Comparison of changes in Intracranial pressure and Intraocular pressure: Comparison of changes in Intracranial pressure and Intraocular pressure with Ketofol(1:1) versus Propafol as ind

Eligibility

Inclusion criteria

Inclusion criteria: 56 patients in the age group of 18-60 years belonging to ASA 1 and 2 undergoing surgery under general anaesthesia requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Refusal of study, pre-existing increase in IOP(Glaucoma), hypertension,obesity (BMI >30kg/m2), traumatic brain injury,space occupying brain lesions, patients on mannitol,seizure disorders,anticipated difficult airway, pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Intracranial pressure by measuring optic nerve Sheath diameterTimepoint: 1.baseline 2.before intubation 3.10minutes after intubation	—

Secondary

Measure	Time frame
Intraocular pressureTimepoint: 1.baseline 2.before intubation 3.10minutes after intubation	—

Countries

India

Contacts

Public ContactDrAjithkumar

Pt. B.D.Sharma PGIMS,Rohtak

kumarajith7541@gmail.com9791836984

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026