Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Pulse pressure variation guided fluid therapy: A 20G arterial line (BD, India) will be inserted into the preferably non-dominant radial artery
after confirming the collateral circulatio
Sponsors
All India Institute of Medical Sciences, Kalyani
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anaesthesiologists [ASA] physical status of 1â??3, adult (18-70 years) patients undergoing elective thoracolumbar spine surgery with instrumentation under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Pre-existing renal impairment, 2. Body mass index (BMI) of >30 kg/ m 2 , 3. Hemodynamic instability requiring vasopressor therapy before surgery, 4. Respiratory system compliance (Crs) of <30 mL/cmH2O, 5. Patients with cardiac arrhythmias, 6. Participants denial to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total volume of fluids administered during the surgeryTimepoint: Measured at the end of the surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute kidney injuryTimepoint: first 48 hours;all-cause mortalityTimepoint: at 30 days;Delayed wound healingTimepoint: postoperative till discharge;Length of hospital stayTimepoint: at discharge;Postoperative deliriumTimepoint: postoperative;Postoperative nausea and vomiting (PONV)Timepoint: First 48 hours;Requirement blood transfusionTimepoint: Intraoperative period;Serum lactate levelsTimepoint: End of surgery;Urine outputTimepoint: Intraoperative;visual lossTimepoint: postoperative | — |
Countries
India
Contacts
Public ContactDr Sekar L
All India Institute of Medical Sciences, Kalyani, West Bengal, India
Outcome results
None listed