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A Clinical trail comparing two drugs - lignocaine and dexmedetomidine in maintaining stable heart rate and blood pressure during laparoscopic surgeries.

Comparison of Intravenous Lignocaine with Dexmedetomidine Infusion in Attenuating Pressor response to Pneumoperitoneum during Laparoscopic Surgeries - A Double Blind Randomized Control Trail

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/052019
Enrollment
81
Registered
2023-04-26
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K36- Other appendicitis Health Condition 2: K810- Acute cholecystitis Health Condition 3: N832- Other and unspecified ovarian cysts

Interventions

Intervention1: DEXMEDITOMEDINE: Dexmedetomedine is a alpha 2 adrenergic receptor agoist. It has anaesthetic sparing, analgesic, sedative, anxiolytic and sympatholytic effects. Intervention2: Lignocain

Sponsors

Mahatma Gandhi Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to America Society of Anaesthesiologists (ASA) 1 and ASA 2 physical status.

Exclusion criteria

Exclusion criteria: Emergency surgeries. Patients with reduced autonomic control like elderly patient, uncontrolled diabetic patient. Patients with pre operative hypotension, bradycardia, dysrhythmia, severe cardiac diseases, complete heart block. Patients on treatment with beta blockers. Patients with hepatic or renal dysfunction. Obese patients, patients with history of obstructive sleep apnea. Pregnant patients. Patients with allergies to any component of the drugs being used. Patients with high risk of bleeding and high chance of laparoscopic surgery being converted open surgery.

Design outcomes

Primary

MeasureTime frame
To measure and compare the mean arterial pressure in the three group of patients (lignocaine group, Dexmedetomidine group, Normal saline group)Timepoint: At various time points durging the surgery.—

Secondary

MeasureTime frame
To measure and compare the hemodynamic parameters (heart rate, systolic blood pressure and diastolic blood pressure) in the three group of patients (lignocaine group, Dexmedetomidine group, Normal saline group)Timepoint: At various time points durging the surgery.;To compare intraoperative opioid requirements in the three group of patients (lignocaine group, Dexmedetomidine group, Normal saline group)Timepoint: Intraoperative duration;To compare the postoperative pain scores using VNRS in the three group of patients (lignocaine group, Dexmedetomidine group, Normal saline group)Timepoint: Postoperative period—

Countries

India

Contacts

Public ContactDr Ramanathan R

Sri Balaji Vidyapeeth University (Deemed to be University).

drgayatrimishra@gmail.com9894354068

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026