Evaluation of effectiveness of advanced platelet rich fibrin (A-PRF) with demineralized freeze-dried bone allograft (DFDBA) on soft and hard tissues alterations placed into fresh extraction sockets following an immediate implant placement: A single arm clinical & radiographic study

Evaluation of effectiveness of advanced platelet rich fibrin (A-PRF) with demineralized freeze-dried bone allograft (DFDBA) placed into fresh extraction sockets with immediate implant placement: A clinical and radiographic study.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/04/051987

Enrollment

Registered

2023-04-26

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K084- Partial loss of teeth

Interventions

Intervention1: A-PRF with DFDBA: We will place A-PRF and DFDBA into horizontal gap distance of more than 1.5 mm in immediate implant placement. Intervention2: A-PRF and DFDBA: We will place A-PRF and

Eligibility

Inclusion criteria

Inclusion criteria: 1. Teeth which needs extraction due to fracture of root residual roots, internal and external resorption, endodontic failures, non-restorable carious lesions, over-retained deciduous teeth. 2. Good oral hygiene with full mouth plaque score 3. Thick gingival biotype. 4. Intact alveolar bony walls appeared both clinically and radiographically. 5. Atleast 4mm bone must be present below root apex. 6. D1, D2 bone quality. 7. The horizontal distance between the implant body and inner surface of buccal wall should be more than 1.5 mm.

Exclusion criteria

Exclusion criteria: 1. Compromised general health conditions that would compromise the bone healing process e.g. (diabetes, blood disorders, osteoporosis and allergies to titanium etc). 2. Severe maxilla-mandibular space discrepancies. 3. Para functional habits (bruxism or clenching). 4. Teeth with interdental spacing/ Proclinated teeth/Rotated or mal-aligned anterior teeth. 5. History of alcoholism, excessive smoking or drug abuse. 6. D-3 and D-4 bone quality. 7. Width of keratinized gingiva less than 2mm at implant site. 8. Debilitating tempromandibular (TMJ) joint pathosis. 9. Untreated dental diseases. 10. Pregnant and lactating mother.

Design outcomes

Primary

Measure	Time frame
Vertical and horizontal crestal bone changes around immediately placed implants.Timepoint: At baseline, 3 months after implant placement and 6 months after final prosthesis.	—

Secondary

Measure	Time frame
Implant mobiliy.Timepoint: Baseline, 3 months, 6 months after final prosthesis.	—

Countries

India

Contacts

Public ContactSneha Chandrakant Dare

Department of Periodontics, Sharad Pawar Dental College, Sawangi (Meghe)

pavbajaj@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026