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Evaluating dexamethasone vs dexmedetomidine in preventing nausea and vomiting in post-operative period in patients undergoing laparoscopic surgery under general aneasthesia.

A randomized comparative control study on effects of dexmedetomidine versus dexamethasone on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic surgery under general anaesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/051958
Enrollment
105
Registered
2023-04-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Dexmedetomidine.: patient allocated in the group will receive intravenous Inj. Dexmedetomidine in the dosage of 1 microgram/kilogram of bodyweight in 100ml normal saline ove

Sponsors

Suchana Maji
Lead Sponsor
Subharti Medical College
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ASA physical status I and II, both gender in the mentioned age group who will give written informed consent.

Exclusion criteria

Exclusion criteria: Patients with ASA physical status III of greater. Severe cardiorespiratory,hepatic,renal,neurological or endocrinal disease. Bradycardia(Heart Rate Pregnant and lactating women. Obesity(BMI >30kg/m2). Diabetes mellitus. Patientswith known hypersensivity of drug allergies. Patients who had taken H2 antagonists,antiemetic or psychoactive medication. Nausea, retching,or vomiting within 48hours before surgery. History of Motion sickness. Patients who refuse to participate in the study.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately.Timepoint: Baseline Before Administration Of Drug After administration of Drug During Intubation After Intubation 45 mins Intraoperatively At the end of Surgery 15 minutes postoperatively 2 hours postoperatively 6 hours postoperatively 12 hours postoperatively

Secondary

MeasureTime frame
To compare and evaluate incidence of rescue antiemetic used with dexmedetomidine and dexamethasone. To compare and evaluate side effects of dexmedetomidine and dexamethasone. To compare and evaluate patient satisfaction with Post-opeartive Nausea and vomiting.Timepoint: Patients satisfaction score will be recorded 12 hours post-opearatively.

Countries

India

Contacts

Public ContactDrSuchana Maji

Subharti Medical College and Hospital

hsminhas28@yahoo.co.in9472212523

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026