Health Condition 1: C50- Malignant neoplasm of breast
Conditions
Interventions
Intervention1: standard arm: patients will receive locoregional radiotherapy to a total dose of 40Gyin 15#s over a period of 3 week
Control Intervention1: test arm: patients will receive locoregional
Sponsors
MAHAMANA PANDIT MADAN MOHAN MALAVIYA CANCER CENTERCANCER CENTER
Eligibility
Inclusion criteria
Inclusion criteria: Histologically proven breast cancer Age more than 18 years Patients having cT4 disease with or without nodes (confirmed clinically or radiologically) Breast cancer patients with cT3 lesion with at least N1 nodes (confirmed clinically or radiologically) Breast cancer patient with any T with N2 and N3 nodes (confirmed clinically or radiologically) Any patient with >cT3 or cN2 node undergoing NACT prior to surgery (confirmed clinically or radiologically) Surgery must be mastectomy with adequate nodal clearance (minimum 10 nodes dissected and examined in histopathology) Willing to give consent
Exclusion criteria
Exclusion criteria: Patient having IMN node at presentation Patient having cT1T2 and N0-N1 disease and cT3N0 disease Patient undergoing BCS Pre-existing known cardiac comorbidity except Hypertension Prior radiotherapy to any other site Patient having bilateral breast cancer Patient who could not complete their planned chemotherapy. Patient who have undergone immediate reconstruction of their breast Patients in whom the dosimetric criteria is not met.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease free survivalTimepoint: at 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Loco regional recurrence Metastasis-free survival Overall survival Acute and late morbidity Quality of Life Timepoint: at 5 years | — |
Countries
India
Contacts
Public ContactLINCOLN PUJARI
MAHAMANA PANDIT MADAN MOHAN MALAVIYA CANCER CENTER
Outcome results
None listed