FindTrial
Sign In

Cerebral blood flow and brain oxygenation during anaesthesia in aneurysm patients undergoing surgery

Comparison of cerebral blood flow velocity, cerebral auto regulation and regional oxygen saturation between desflurane and propofol anesthesia in ruptured anterior circulation aneurysm patients undergoing clipping- A prospective observational study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/04/051947
Enrollment
300
Registered
2023-04-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I60- Nontraumatic subarachnoid hemorrhage

Interventions

Intervention1: Propofol based anesthesia induction and maintainance in aneurysm clipping patients: Propofol based anesthesia induction and maintainance in aneurysm clipping patients- with BIS monitori

Sponsors

NIMHANS DEPT OF NEUROANESTHESIA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Ruptured anterior circulation aneurysm within one week of ictus undergoing surgical clipping 2.WFNS grade 1-2

Exclusion criteria

Exclusion criteria: 1. Pre-existing cardiac/ renal/ liver failure 2. Contraindication for propofol administration 3. Refusal of consent 4. Inadequate TCD window 5. Internal Carotid artery stenosis/ plaque visualized in CT Angio. 6. Change of anaesthetics agent

Design outcomes

Primary

MeasureTime frame
To determine and compare the changes in cerebral blood flow velocity, autoregulation and rSO2 between desflurane and propofol based anaesthesia.Timepoint: 10 MIN PRIOR TO INDUCTION OF ANESTHESIA, 10 MIN POST INTUBATION ON ACHIEVING STEADY STATE AFTER ANESTHESIA IS ESTABLISHED.—

Secondary

MeasureTime frame
To determine the effect of cerebral hemodynamic changes of the two agents on short-term neurological outcome in aneurysm patients undergoing clipping.Timepoint: POST OPERATIVE PERIOD IMMEADIATELY AFTER SURGERY - VITAL PARAMETERS, NUMBER OF DAYS OF HOSPITAL STAY , NEUROLOGICAL ASSESSMENT AT THE TIME OF DISCHARGE VIA GCS , GOS SCLAES , ANY MORTALITY , ANY DELAYED ISCHEMIA;To determine the relationship of Cerebral blood flow Velocity, auto-regulation with rSO2( regional saturation ) when anesthesia is provided with two different agents i.e propofol and desflurane.Timepoint: 10 MIN PRIOR TO INDUCTION OF ANESTHESIA, 10 MIN POST INTUBATION ON ACHIEVING STEADY STATE AFTER ANESTHESIA IS ESTABLISHED.—

Countries

India

Contacts

Public ContactDr Madhusudan Reddy

NIMHANS

krmsr2000@yahoo.com9880103088

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026