growth factor concentrate in knee osteoarthritis

to compare the efficacy of intra-articular autologous growth factor concentrate and platelet-rich plasma injections in knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/04/051860

Enrollment

Registered

2023-04-21

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Growth Factor Concentrate: intra-articular injections of autologous growth factor concentrate made from 4ml of the patients blood Control Intervention1: Platelet Rich Plasma: intra-arti

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are satisfying the American College of Rheumatology (ACR) criteria for diagnosis of osteoarthritis knee. Radiological findings of Grade II and III Osteoarthritis of the knee joint, according to the Kellgren-Lawrence scale.

Exclusion criteria

Exclusion criteria: Any malignancy. Drug Abuse Gouty Arthritis /inflammatory arthritis, Secondary Osteoarthritis Active knee infection. Patient Suffering from Anemia, Disorders of Bleeding Rheumatoid Arthritis Genu varum/valgum >5 degree Uncontrolled Diabetes Mellitus Ligamentous instability of knee (Tested by Clinical examination) Osteoarthritis of any other joint Patient in whom MRI is contraindicated.

Design outcomes

Primary

Measure	Time frame
serum Coll2-1 levels knee MRITimepoint: baseline and 9 months	—

Secondary

Measure	Time frame
visual analogue scale WOMAC scoreTimepoint: baseline 6-month follow-up 9-month follow-up	—

Countries

India

Contacts

Public ContactProfessor Amit Saraf

professor and head of department, department of orthopaedics, teerthanker mahaveer medical college

amitsaraf_75@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026