Health Condition 1: 1- Obstetrics
Conditions
Interventions
Intervention1: Carbetocin: single dose of 100 mcg Intravenous bolus in 10 ml of NS over 1 minute.
No further repeat dose will be given
Control Intervention1: Oxytocin: Total Dose 15 U IV. (5 IU in 1
Sponsors
ABVIMS and Dr RML Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Uncomplicated Term Pregnant Women with singleton pregnancy scheduled for elective caesarean section under spinal anaesthesia
Exclusion criteria
Exclusion criteria: Pregnant Women with American Society of Anaesthesiologists physical status III and above. Women having conditions with increased risk of uterine atony and PPH such as, pre eclampsia, eclampsia, multiple gestation, placenta previa, uterine fibroids and previous history of uterine atony and PPH. Females with a history of bleeding diasthesis or thromboembolic diseases. Women who are a known case of chronic medical diseases(renal, hepatic or cardiovascular diseases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of change in mean arterial pressure after administration of the study drugsTimepoint: Time of skin incision(T0) 1 Minute(T1) 3 Minutes(T3) 5 Minutes(T5) 10 Minutes(T10) | — |
Secondary
| Measure | Time frame |
|---|---|
| Averse effects of the two drugs, if anyTimepoint: Every five minutes from the time of administration of the drug till the end of the surgery;Changes in heart rate after administration of study drugsTimepoint: Time of skin incision(T0) 1 Minute(T1) 3 Minutes(T3) 5 Minutes(T5) 10 Minutes(T10);Need for use of additional uterotonicsTimepoint: In first 24 hours after surgery;Uterine tone after administration of study drugsTimepoint: 3 Minutes(T3) 5 Minutes(T5) 10 Minutes(T10) | — |
Countries
India
Contacts
Public ContactVaishali Sharma
ABVIMS and Dr RML Hospital
Outcome results
None listed