Health Condition 1: F112- Opioid dependence
Conditions
Interventions
Intervention1: Naltrexone and N-Acetyl cysteine: When the COWS is less than 5 , patients will be rated on OCDUS, DDQ and MRS of Nucleus Accumbens will be done. Patients will receive Naltrexone 50 mg a
Sponsors
Central Institute Of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. In-patients of male sex aged between 18-60 years 2. Those who fulfill the criteria for Mental and Behavioral disorders due to use of Opioids, Dependence syndrome (F11. 2X) according to International Classification of Diseases 10th version (ICD-10) - Diagnostic Criteria for Research (DCR) by World Health Organization (WHO, 1992) 3. Subjects giving written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patient with any co morbid substance dependence with opioid (except Nicotine and Caffeine) 2. Patients with currently serious physical problem and organic brain disorder 3. History of any other psychiatric illness or mental retardation 4. Patients having any metallic implants/parts in body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in scores of OCDUS and DDQ .Timepoint: Reduction in scores of OCDUS and DDQ at baseline and after 4 weeks of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect on craving and its relationship with Glutamate level in Nucleus Accumbens.Timepoint: Effect on craving and its relationship with Glutamate level in Nucleus Accumbens at baseline and 4 weeks after treatment. | — |
Countries
India
Contacts
Public ContactDr Sunilkumar R Suryavanshi
Central Institute of Psychiatry
Outcome results
None listed