Health Condition 1: A170- Tuberculous meningitis
Conditions
Interventions
Intervention1: Ibuprofen with standard care: oral ibuprofen 10 mg/kg/dose BD for 4 weeks along with standard care of treatment for TB meningitis
Control Intervention1: Standard care: standard care of
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Presenting to department of pediatrics, AIIMS Rishikesh with a diagnosis of TB meningitis as per Maraiâ??s criteria and parents willing to comply with the study protocol and follow up
Exclusion criteria
Exclusion criteria: 1. Preexisting major chronic systemic illness including cardiovascular, respiratory, gastrointestinal system or chronic renal disease 2. Preexisting developmental delay or intellectual disability 3. Already started on ATT for >2 weeks before presenting to our center 4. Caregivers not giving informed consent 5. History of allergy to ibuprofen previously 6. Deranged RFT (serum urea, creatinine or blood urea-nitrogen 7. Total platelet count 8. HIV positivity 9. Children in whom ibuprofen canâ??t be administered orally or through nasogastric tube within 72 hours of presenting to our institute due to clinical contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in FSS scale score at 4 weeks as compared to baseline in both groupsTimepoint: Change in FSS scale score at 4 weeks as compared to baseline in both groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in FSS score at 12 weeks as compared to baseline 2. Change in PCPC score at 4 and 12 weeks as compared to baseline 3. Change in radiological severity score at 12 weeks as compared to baseline 4. Mortality at 4 and 12 weeks in both arms 5. Duration of hospitalization in both arms 6. Number of patients with paradoxical reaction within 12 weeks 7. Social quotient by VSMS at 12 weeks 8. Childhood Behavioural Checklist internalizing, externalizing and total score at 12 weeksTimepoint: 4 and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Indar Kumar Sharawat
All India Institute of Medical Sciences, Rishikesh
Outcome results
None listed