A comparative study of two modes of ventilation in Chronic Obstructive Lung Disease

Efficacy of High Flow Nasal Cannula versus Non Invasive Ventilation Bilevel Positive Airway Pressure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease-A randomized control study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/04/051659

Enrollment

Registered

2023-04-17

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J439- Emphysema, unspecified

Interventions

Intervention1: High Flow Nasal Cannula: A nasal cannula which will deliver high flow oxygen will be used for 6 hours and arterial blood gas analysis will be repeated after 2 and 6 hours respectively C

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with acute exacerbation of Chronic Obstructive Pulmonary Disease with Moderate Respiratory Failure PCO2:45-65mmHg;pH:7.25-7.35

Exclusion criteria

Exclusion criteria: 1.Patients who are having Type I respiratory failure 2.Massive aspiration 3.Persistent inability to remove respiratory secretions 4.Inability to tolerate NIV BIPAP/NIV BIPAP failure 5.Status post respiratory or cardiac arrest 6.Severe ventricular or supraventricular arrhythmias 7.Patient who got neck and face trauma

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of High Flow Nasal Cannula with Non Invasive Ventilation Bilevel Positive Airway Pressure in Acute exacerbation of Chronic Obstructive Pulmonary Disease by clinical parameters and Arterial Blood Gas AnalysisTimepoint: Arterial Blood Gas analysis at 2 and 6 hours after initiation of therapy	—

Secondary

Measure	Time frame
To compare the efficacy of High Flow Nasal Cannula with Non Invasive Ventilation Bilevel Positive Airway Pressure in Acute exacerbation of Chronic Obstructive Pulmonary Disease in terms of patient comfort and adherence to treatmentTimepoint: To assess patient comfort and adherence to treatment after the end of therapy	—

Countries

India

Contacts

Public ContactSrinath S

Sri Manakula Vinayagar Medical College and Hospital

nsivagnaname@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026