Comparing Vortioxetine, Escitalopram and fluoxetine on adults with mild and moderate depression

Comparison of response of Vortioxetine, Escitalopram and fluoxetine on adults with mild and moderate depression treated in a tertiary care centre- A simple randomized controlled trial - VEFCR

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2023/04/051622

Enrollment

120

Registered

2023-04-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F30-F39- Mood [affective] disorders

Interventions

Intervention1: Vortioxetine: 10mg to 20mg OD for 6 months Control Intervention1: Escitalopram: 10mg to 20mg OD for 6 months Control Intervention2: Fluoxetine: 20mg to 80mg OD for 6 months

Eligibility

Inclusion criteria

Inclusion criteria: Meet the ICD-11 diagnostic criteria for depression, Age between 18 to 65 years, MADRS score of 7-19 Mild & 20-34 moderate depression and Signs informed consent

Exclusion criteria

Exclusion criteria: Using MINI to screen out people with other Psychiatric illness eg. substance use, mania, eating disorder, MADRS score >34: Severe depression, Pregnant mother and not giving consent

Design outcomes

Primary

Measure	Time frame
Montgomery and Asberg Depression Rating scale, 50% improvementTimepoint: 6 months	—

Secondary

Measure	Time frame
Side-effects experiencedTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Arul Saravanan

SRM Medical College Hospital and Research Centre

janusulo15@gmail.com9790823079

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026