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Under general anesthesia, three loading doses of dexmedetomidine will be compared for controlled hypotension during functional endoscopic sinus surgery.

Comparison of three different loading doses of dexmedetomidine for controlled hypotension during functional endoscopic sinus surgery under general anaesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/051531
Enrollment
60
Registered
2023-04-12
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J329- Chronic sinusitis, unspecified Health Condition 2: J00-J99- Diseases of the respiratory system Health Condition 3: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: Loading dose of 1 micrograms/ kg intravenously 10 minutes before induction of anaesthesia OD Control Intervention1: Dexmedetomidine: Loading dose of 0.8 micrograms/ kg

Sponsors

Pt B D Sharma Pgims Rohtak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Sixty patients aged between 18-60 years of either sex belonging to American Society of Anesthesiology (ASA) I and II scheduled for FESS under general anaesthesia will be included in the study.

Exclusion criteria

Exclusion criteria: 1. Refusal to consent 2. Uncontrolled hypertension 3. Preexisting hypotension (MAP 4. Heart rate 5. Diabetes 6. Coagulation disorders 7. BMI > 35 kg m-2 8. Treatment with beta-blockers 9. Patients scheduled for revision of functional endoscopic sinus surgery 10. Allergy to an alpha 2 adrenergic agonist 11. Pregnancy 12. Anaemia (Hb

Design outcomes

Primary

MeasureTime frame
To achieve and maintain target MAP 60 – 70 mmHg.Timepoint: Before start of surgery 10 minutes after induction of anaesthesia.—

Secondary

MeasureTime frame
1. Changes in hemodynamic parameters like heart rate, mean arterial pressure, 2. Surgical field assessment (Fromme et al. bleeding score) 3. Surgeon’s satisfaction, (Likert scale) 4. Minimum alveolar concentration of inhaled anaesthetics (MAC) 5. Adverse effects, if any Timepoint: observations will be recorded as baseline, 10 minutes after start of dexmedetomidine loading dose infusion, before induction of anaesthesia, 1, 5 & 10 minutes after tracheal intubation, then every 15 minutes till end of surgery and after tracheal extubation, and also in postoperative period.—

Countries

India

Contacts

Public ContactDr Mamta Bhardwaj

Department of Anesthesia and critical care, Pt B D Sharma Pgims Rohtak

drbmamta@gmail.com9812789476

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026