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Role of anesthesia without giving opioids in cognitive dysfunction post operatively among elderly patients undergoing laparoscopic surgeries

The role of opioid-sparing anesthesia in post-operative cognitive dysfunction among elderly patients undergoing laparoscopic surgery, a double blinded randomized control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/051526
Enrollment
100
Registered
2023-04-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F05- Delirium due to known physiological condition

Interventions

Intervention1: Anesthesia with opioids: Opioids will be given during induction, intraoperatively and post operatively for analgesia Anaesthesia will be routinely induced in all the patients with prop

Sponsors

Dr Puneet Khanna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age above 60 years. Undergoing major surgery over 60 minutes Can give informed consent themselves Minimum cognitive performance required to participate is ACE-III score more than 88

Exclusion criteria

Exclusion criteria: Patients with a history suggestive of dementia (either listed in the medical record or reported by the patient) or any neurological disorder. History of alcohol abuse, chronic opioid or other substance abuse History of cerebral surgeries, stroke. History suggestive of psychiatric disease like schizophrenia, dementia, anxiety or other disorder affecting cognition, mental dysfunction Prescription of central nervous system–active medications (eg:antidepressants, antipsychotics, sedatives)

Design outcomes

Primary

MeasureTime frame
Compare the incidence of post operative cognitive decline in elderly patients undergoing laparoscopic surgery under general anesthesia with opioids and opoid free anesthesiaTimepoint: Post-operative delirium: immediately and 24 hours post operatively Post-operative cognitive dysfunction: 24-48 hours and 30 days post operatively—

Secondary

MeasureTime frame
1. To determine the association between opioids and frontal lobe hypoperfusion indicated by using nirs 2. To compare the incidence of post operative delirium 3.To determine the association between cerebral perfusion and incidence of post-operative cognitive dysfunction and delirium Timepoint: Post-operative delirium: immediately and 24 hours post operatively Post-operative cognitive dysfunction: 24-48 hours and 30 days post operatively NIRS monitoring: intra operatively every 10 minutes—

Countries

India

Contacts

Public ContactDr Puneet Khanna

Additional Professor, Department of Anesthesiology, India Institute of Medical Sciences New Delhi

k.punit@yahoo.com9873106516

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026