Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Injection Magnesium sulphate: After arrival of patient to OT baseline vitalswill be recorded. Bispectral index (BIS) electrodes and TOF-Watch SX will be connected. A 18 or 20G periphe
Sponsors
Pt B. D. Sharma University Of Health Sciences, PGIMS,Rohtak, Haryana
Eligibility
Inclusion criteria
Inclusion criteria: American society of Anesthesiology grade I and II between the age of 18-65 years, of either sex and posted for laparoscopic cholecystectomy under general anaesthesia
Exclusion criteria
Exclusion criteria: Patients with major hepatic, renal and endocrine dysfunction, cardiovascular dysfunction; neuromuscular, neurological disorder, atrioventricular conduction disturbance, COPD, asthma, obstructive sleep apnea and haematological disorders. Patients with difficult airway. Patients with known allergy to dexmedetomidine or magnesium sulphate. Pregnancy, obesity (body mass index >30 kg m-2), hypertension, diabetes mellitus, and major systemic illness Patients on treatment with calcium channel blockers, beta-blockers, alpha 2 adrenergic agonists or opioid abuse Any intraoperative surgical complication like prolonged surgery (duration more than two hours) or conversion to open surgery, Patient’s unwillingness to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the changes in HR & MAP during laryngoscopy and intubation, creation & release of pneumoperitoneum and extubation.Timepoint: T0 baseline data T1 following completion of study drug infusion T2 1 minute after induction T3 1 minute after intubation T4 after peritoneal insufflation T5 15 min after peritoneal insufflation T6 after peritoneal deflation T7 1 min after extubation T8 60 min after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To observe and compare intraoperative anaesthesia requirement, extubation time, time to first rescue analgesic requirement and postoperative sedationTimepoint: Intraop requirement of total propofol, fentanyl, muscle relaxant and mean end tidal sevoflurane concentration ;Extubation time; Duration of surgery; Time to first rescue analgesia- time from extubation to time when pain reported by patient was =4 on visual analogue scale. Injection paracetamol l5mg/kg IV will be used ,If the patient doesn’t get relief in 15 min Injection diclofenac 1.5mg/kg will be given; Post op sedation level will be assessed at 1,15,30, 60 min using Ramsay sedation score | — |
Countries
India
Contacts
Public ContactDr Vaishali Gupta
Pt B. D. Sharma PGIMS, Rohtak
Outcome results
None listed