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Benefits of systemically administered omega 3 fatty acids on nuclear factor kappa b levels in patients with rheumatoid arthritis and periodontitis .

Efficacy of systemic administration of Omega 3 fatty acids when used as adjuvants to scaling and root planing on serum Nuclear Factor Kappa B levels in patients with Rheumatoid Arthritis and Periodontitis.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/051411
Enrollment
24
Registered
2023-04-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement

Interventions

Intervention1: Group I 12 Patients with Chronic Periodontitis: 6 patients will take omega 3 fatty acids(500 mg twice daily for 3 months ) and 6 patients will take placebo after scaling and root planin

Sponsors

Panineeya Institute of Dental Sciences and Research centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Rheumatoid arthritis. Patients with Chronic periodontitis. For Periodontitis: 20 teeth should be present with probing pocket depths >= 5mm in one or more sites. Rheumatoid arthritis patients with Anti-CCP levels Positive for antibodies â?? ( >20u/ml)

Exclusion criteria

Exclusion criteria: Pregnant and lactating women, Smokers, Patients with any auto immune or systemic disorder other than Rheumatoid arthritis. Use of Medicines (other than RA medicines) or antibiotics 3 months before the commencement of the study. History of periodontal treatment within 6 months.

Design outcomes

Primary

MeasureTime frame
To evaluate if omega-3 fatty acids have beneficial effects in patients with rheumatoid arthritis and periodontitis when used as adjuvant to non surgical periodontal therapyTimepoint: Baseline and 3 months—

Secondary

MeasureTime frame
Plaque Index(PI), Gingival Index (GI) Probing pocket depths (PPD)Timepoint: base line and 12 weeks after non surgical periodontal therapy—

Countries

India

Contacts

Public ContactDr GUNDELLY MRUNALINI

Panineeya Institute of Dental Sciences and Research centre.

rekhasarat2304@gmail.com04024141177

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026