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Assessing levels of Periostin and DKK-1, for periodontal disease and diabetes before and after treatment.

"Correlation of Periostin and Dickkopf-Related Protein-1 (DKK-1)levels in gingival crevicular fluid and serum in periodontitis subjects with and without Type 2 Diabetes Mellitus before and after non-surgical periodontal therapy.- A Clinico Biochemical Study"

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/04/051408
Enrollment
120
Registered
2023-04-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Procedure - Non -surgical periodontal therapy(NSPT): one time (frequency)of Non -surgical periodontal therapy(NSPT) and follow up after3 months Control Intervention1: Non -surgical per

Sponsors

Suganya T
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: subjects with diagnosis of stage III grade B periodontitis. well controlled diabetes subjects will be selected. subjects should not have atleast 20 natural teeth excluding third molars. subjects with normal lipid profile.

Exclusion criteria

Exclusion criteria: pregnant and lactating females. smokers and alcoholics subjects with other systemic conditions rheumatoid arthritis, cardiovascular abnormalities, use of immunosuppressive medications, and other infectious chronic diseases.

Design outcomes

Primary

MeasureTime frame
To compare and correlate the clinical parameters and levels of Periostin and DKK1 in GCF and Serum in periodontally healthy, stage III Grade B periodontitis subjects with and without Type 2 Diabetes mellitus before and 3 months after NSPTTimepoint: 12 weeks—

Secondary

MeasureTime frame
1. To estimate the levels of Periostin and DKK-1 in the gingival crevicular (GCF) and serum in systemically and periodontally healthy subjects, Stage III Grade B periodontitis patients with and without Type 2 diabetes mellitus. 2.To estimate the levels of Periostin and DKK-1 in the GCF and serum in Stage III Grade B periodontitis patients with and without Type 2 diabetes mellitus patients 3 months after NSPT. 3. To explore the possibility of using DKK-1 as a bone resorptive marker in periodontal disease progression.Timepoint: 12 weeks—

Countries

India

Contacts

Public ContactSuganya T

The oxford dental college

Pradeepraju58@yahoo.co.in9845081190

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026