Health Condition 1: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
None listed
Sponsors
Dr Irene Ann Thomas
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients who have not received any periodontal treatment in previous six months. 2. Patients diagnosed with T2DM as per American Diabetes Association criteria (2019). 3. Patients with a diagnosis of Generalized Periodontitis as per World Workshop Classification criteria (2017).
Exclusion criteria
Exclusion criteria: 1. Smokers and alcoholics. 2. Patients with systemic diseases like hypertension, cardiovascular diseases, rheumatoid arthritis, tumours, autoimmune diseases and renal diseases. 3. Pregnant, lactating females and post menopausal women. 4. Any other systemic disease which can alter the course of periodontal disease. 5. Patients on any medication like anti-inflammatory drugs, antibiotics and anti-epileptic drugs in the past 6 months. 6. Vitamin D deficiency.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Not applicableTimepoint: Not applicable | — |
Primary
| Measure | Time frame |
|---|---|
| 1. To estimate serum and salivary levels of Klotho, Uncoupling protein 2 and Interleukin-12 in periodontally healthy, generalized periodontitis patients with / without T2DM and T2DM patients. 2. To explore the association between Klotho, Uncoupling protein 2 and Interleukin-12 in both periodontitis and T2DM. 3. To compare between the serum and salivary levels of Klotho, Uncoupling protein 2 and Interleukin-12 in periodontitis and T2DM patients and to correlate their levels with clinical parameters. 4. To explore the possibility of assessing Klotho, Uncoupling protein 2 and Interleukin-12 as markers for both periodontal disease and T2DM.Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr Irene Ann Thomas
The Oxford Dental College
Outcome results
None listed