Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Ketofol: We will compare the effect of ketofol and propofol on hemodynamic stability, cerebral oxygenation, intraoperative brain relaxation and neuroprotection in patients undergoing ne
Sponsors
GB Pant Institute Of Postgraduate Medical Education And Research
Eligibility
Inclusion criteria
Inclusion criteria: All ASA I and II patients, greater than 18 years of age, scheduled for craniotomy and tumor decompression in the sitting position
Exclusion criteria
Exclusion criteria: Patients with ASA physical status III & IV History of ischemic heart disease, cardiac rhythm disturbances, intracardiac shunts Uncontrolled BP Renal or Hepatic dysfunction Allergic history Diabetes having autonomic dysfunction History of psychiatric diseases Severe cervical canal stenosis Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension among the two groups as evaluated by a greater than 20 % decrease in the mean arterial pressure from the baseline or a MAP less than 65mmHgTimepoint: Time points when there is a fall in MAP by 20 % or MAP less than 65mmHg | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunomodulatory and neuroprotective efficacy as assessed by Interleukin 6 (IL-6) and High sensitive CRP (HsCRP)Timepoint: Before induction and at the end of surgery;Quality of brain relaxationTimepoint: At the time of dura opening;To assess the Cardiac indices by non invasive cardiac output monitor and cerebral oxygen saturation with non invasive cerebral oximetryTimepoint: Awake supine Awake sitting 5 mins post induction Prior to and after application of elastic bandages 5 mins after achieving the sitting position During surgery every 15 mins 5 mins after repositioning the patient in supine position;To assess the following parameters between two groups Requirement of fluid boluses, vasoconstrictors and inotropes to treat hypotensionTimepoint: At times when there is fall in MAP (less than 65mmHg) | — |
Countries
India
Contacts
Public ContactDr Neha Bhandari
GB Pant Institute of Postgraduate Medical Education and Research
Outcome results
None listed