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COMPARISON OF BIOMARKERS IN PATIENTS DIABETIC MELLITUS AND GUM DISEASES

EVALUATION AND COMPARISON OF SERUM LEVELS OF sTWEAK, OMENTIN, AND TNF-ALPHA IN SUBJECTS WITH CHRONIC PERIODONTITIS AND TYPE 2 DIABETES MELLITUS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/04/051270
Enrollment
60
Registered
2023-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

None listed

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Individual with age ranging from 30-70 years 2.Subjects with minimum 15 teeth or more 3.Generalized chronic periodontitis patients exhibiting Pocket depth >4mm and CAL of >3mm in more than 30% diseased sites,(According to the AAP classification 2017 stage III grade B in group I and stage III grade C in group II) GROUP SPECIFIC INCLUSION CRITERIA GROUP I: Individuals without systemic diseases and chronic periodontitis GROUP II: Generalized chronic periodontitis patients exhibiting Pocket depth >4mm and CAL of >3mm in more than 30% diseased sites According to American Diabetic Association(ADA) classification of glycaemic control- GROUP III: Generalized chronic periodontitis patients with type 2 diabetes mellitus exhibiting good control GROUP IV: Generalized chronic periodontitis patients with type 2 diabetes mellitus exhibiting poor control

Exclusion criteria

Exclusion criteria: 1.Patients with systemic condition influencing the course of periodontal disease other than diabetes 2.Patients with haemoglobinopathies, bleeding and clotting disorders that will influence HbA1c level. 3.History of periodontal treatment within the previous six months 4.Antimicrobial therapy, immunosuppressant or lipid lowering drugs within the past 3 months 5. Smokers and alcoholics 6.Pregnancy and lactation

Design outcomes

Primary

MeasureTime frame
1. Plaque Index (Sillness and Loe, 1964)(PI) 2.Gingival Index(Loe and Sillness,1963)(GI) 3.Bleeding on probing(BOP) 4.Probing Depth (PD) 5.Clinical attachment level (CAL) 6.HbA1c level (According to American Diabetic Association,ADA) Timepoint: BASELINE AND 3 MONTHS—

Secondary

MeasureTime frame
To compare and correlate sTWEAK, Omentin-1 and TNF-α levels with clinical parameters (bleeding on probing, probing pocket depth and clinical attachment level) in all 4 groups before and after non-surgical periodontal therapy Timepoint: BASELINE AND 3 MONTHS—

Countries

India

Contacts

Public ContactDR DEEPA PONNAIYAN

SRM Dental College, Ramapuram, Tamil Nadu

deepa_ponnaiyan@yahoo.co.in9884358568

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026