Health Condition 1: R688- Other general symptoms and signs
Conditions
Interventions
Intervention1: IV Lorazepam: Lorazepam will be delivered via a syringe pump at a concentration of 0.16mg/ml
Control Intervention1: IV midazolam: IV midazolam will be delivered via a syringe pump at a
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: All adults of either gender between the age of 18 â?? 85 years on mechanical ventilation requiring sedation for at least 3 days not included in the exclusion criteria.
Exclusion criteria
Exclusion criteria: 1. Consent refusal 2. Patients with h/o chronic benzodiazepine use 3. Patients with h/o allergy to either drug 4. Patients who require pharmacologic neuromuscular blockade for maintenance of mechanical ventilation 5. Patients who are mechanically ventilated for 6. Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of adequate sedation [expressed as percentage of time patient will be sedated at the desired level as determined by Richmond Agitation Sedation Scale (RASS) Score, measured from start of the infusion, until 24 hours after discontinuation of the drug or death of the patient].Timepoint: measured from start of the infusion, until 24 hours after discontinuation of the drug or death of the patient | — |
Secondary
| Measure | Time frame |
|---|---|
| Average cost of study medication per dayTimepoint: expressed in INR;Duration of mechanical ventilationTimepoint: measured in hours;Incidence of complications such as metabolic acidosis, hypotension or any other untoward adverse eventsTimepoint: expressed in whole number; measured during the study period;Length of hsopital stayTimepoint: days;Length of ICU stayTimepoint: days;Number of infusion rate adjustmentsTimepoint: expressed in whole number; measured during the study period;Number of therapeutic failuresTimepoint: expressed in whole numbers; measured during the study period;Time taken for extubation after discontinuation of the drugTimepoint: measured in hours;Time to achieve initial desired level of sedation.Timepoint: measured in hours (from starting of infusion) | — |
Countries
India
Contacts
Public ContactDr Shivkumar Iyer
Bharati Vidyapeeth (DTU) Medical College
Outcome results
None listed