Evaluation of Serum Biomarkers levels using two different Root Canal Sealers in endodontic patients

Change in Serum Biomarkers levels in patients of Apical Periodontitis after Root canal treatment using two different Root Canal Sealers: A Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/051190

Enrollment

Registered

2023-03-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin Health Condition 2: K045- Chronic apical periodontitis

Interventions

Intervention1: Bioceramic based Root Canal Sealer group (BioRoot-RCS, Septodont): Gutta percha coated with sealer will be placed inside root canal and rotated 3 times in anticlockwise motion and then

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between the age group of 18 years to 65 years. 2. Posterior teeth diagnosed with apical periodontitis, based on clinical and radiographic examination (Loss of lamina dura and widening of PDL space).

Exclusion criteria

Exclusion criteria: 1. History of any chronic diseases (such as diabetes mellitus, known cardiac conditions, kidney disease, liver disease, autoimmune disorders and malignant neoplasms )and abnormal physical examination findings, especially signs and symptoms of any infectious disease. 2. Subjects with poor oral hygiene, deep periodontal pockets, mild/ moderate/ severe periodontitis. 3. Recent hospitalization within the last 1 year. 4. Patients who have taken systemic antibiotics/corticosteroids within the past three months.

Design outcomes

Primary

Measure	Time frame
To compare the impact of zinc oxide eugenol based (Tubli-Seal, Kerr) and bioceramic based root canal sealer (Bio Root RCS, Septodont) placed during root canal obturation on change in serum inflammatory as well as anti-inflammatory biomarker in systemically healthy adults.Timepoint: Pre-operative, 15 days Post-operative, 60 days Post-operative.	—

Secondary

Measure	Time frame
To compare the impact of zinc oxide eugenol based (Tubli-Seal, Kerr) and bioceramic based root canal sealer (Bio Root RCS, Septodont) placed during root canal obturation on radiographic periapical healing.Timepoint: Pre-operative, 15 days Post-operative, 60 days Post-operative.	—

Countries

India

Contacts

Public ContactDr Jyoti Sharma

All India Institute of Medical Sciences, Jodhpur

kumarpr@aiimsjodhpur.edu.in9818402220

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026