None listed
Conditions
Interventions
Control Intervention1: Isoflurane: Isoflurane is an inhalational anesthetic agent and is approved for anesthesia in donor hepatectomy patients
Isoflurane (inhalational agent) is titrated to maintain
Sponsors
Institute of liver and biliary sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adults above 18 years old, posted for right lobe hepatectomy
Exclusion criteria
Exclusion criteria: 1. Patient denying consent 2. Donors undergoing left, left lateral, right extended lobe hepatectomy 3. Any modification in anaesthesia treating protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To compare the serum levels of liver regeneration markers such as Hepatocyte growth factor, Vascular endothelial growth factor, Angiopoietin-2, Serum bile acid and Stromal cell derived factor-1 during baseline, POD 1, 4 and 7 in propofol and isoflurane group 2. To compare regeneration liver volume (CT Volumetry) at POD 7 and 14 in both the groupsTimepoint: Baseline, POD 1, 4 and 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the liver function tests (Sr. Bilirubin, AST, ALT, GGT, albumin, platelet count, prothrombin time, INR, lactate) on baseline, POD 0, POD 1(12hrs and 24hrs) and POD 7 2. To compare the intraoperative hemodyanamic parameters (Blood pressure, heart rate, central venous pressure) 3. To compare the awakening time (the time elapsed between discontinuation of anesthetics and opening of eyes) 4. To compare the incidence of immediate postoperative recovery after extubation (delirium, nausea and vomitting)Timepoint: baseline, POD 0,1,7 | — |
Countries
India
Contacts
Public ContactNeha Garg
Institute of liver and biliary sciences
Outcome results
None listed