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Non-operative Treatment versus Appendectomy for acute uncomplicated appendicitis

NON-OPERATIVE TREATMENT VERSUS APPENDICECTOMY FOR ACUTE UNCOMPLICATED APPENDICITIS IN ADULTS: A RANDOMIZED CONTROLLED TRIAL IN A TERTIARY HOSPITAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/051040
Enrollment
200
Registered
2023-03-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K358- Other and unspecified acute appendicitis Health Condition 2: K358- Other and unspecified acute appendicitis

Interventions

Intervention1: NON-OPERATIVE MANAGEMENT(NOM): Patients in NOM group will be given intravenous Ceftriaxone ( 50 mg/kg in two divided schedule) and metronidazole (20 mg/kg/day in three divided doses) al

Sponsors

MIDNAPORE MEDICAL COLLEGE AND HOSPITAL
Lead Sponsor
SUBHENDU BIKAS SAHA
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: All patients aged between 10 to 60 years of age presented to surgical department with diagnosis of acute appendicitis.

Exclusion criteria

Exclusion criteria: 1.Diffuse peritonitis 2.Appendicular mass 3.Appendicular abscess 4.Antibiotic documented allergy 5.Ongoing previously commenced antibiotic therapy 6.Previous appendectomy 7. Positive pregnancy test 8. IBD history or suspicion of IBD re-occurrence 9. Modified Alvarado score below 7.

Design outcomes

Primary

MeasureTime frame
Compare the outcome of non-operative treatment (NOM) with antibiotics versus surgical management of uncomplicated AA in the specified age range. Evaluate the effectiveness and short as well as long term outcomes of NOM of uncomplicated AA. Timepoint: 1 year

Secondary

MeasureTime frame
To identify clinical, laboratory and imaging findings or the factors that are predictive of failure of conservative management(NOM) in acute appendicitis and/or relapse of appendicitis and need for appendicectomy within one year. Timepoint: 1 year.

Countries

India

Contacts

Public ContactSubhendu bikash Saha

MIDNAPORE MEDICAL COLLEGE

sunsubg@gmail.com9064071218

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026