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Efficacy of adjunctive cerebellar HD-tDCS on craving in Alcohol Dependence Syndrome.

Efficacy of adjunctive cerebellar HD-tDCS on craving in Alcohol Dependence Syndrome: A cue based fMRI BOLD activation study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/051030
Enrollment
40
Registered
2023-03-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: High definition transcranial direct current stimulation: The active cathode electrode will be placed over the right cerebellum 1 cm below and 4cm right to the inion. The stimulating ele

Sponsors

Central Institute of Psychiatry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects diagnosed with mental and behavioral disorders due to use of alcohol, dependent syndrome,currently using the substance (F10.24) as per International Classification of disease 10th (ICD-10, DCR) Diagnostic Criteria for Research. 2. Age between 18-50 years 3. Ready to give informed consent 4. Right-handed 5. Educated up to class VIII or above 6. Clinical institute withdrawal assessment for alcohol revised (CIWA-AR) protocol score less than 10.

Exclusion criteria

Exclusion criteria: 1. Subject having alcohol related complicated withdrawal. 2. Any comorbid substance use disorder except nicotine and caffeine. 3. Participants with hepatic derangements or impaired liver function test (LFT). 4. Patients with metal in cranium, pacemaker, history of significant traumatic brain injury; history of epilepsy and cerebrovascular accident(CVA); skin problems such as dermatitis, psoriasis, or eczema over the scalp. 5. Participants having any contraindications for undergoing HDtDCS and fMRI study.

Design outcomes

Primary

MeasureTime frame
Reduction in scores of cravings as rated by Alcohol Craving Questionnaire (ACQ) and Obsessive-Compulsive Drinking Scale (OCDS) after 2 and 4 weeks of HDtDCS treatment.Timepoint: Reduction in scores of cravings as rated by Alcohol Craving Questionnaire (ACQ) and Obsessive-Compulsive Drinking Scale (OCDS) after 2 and 4 weeks of HDtDCS treatment.—

Secondary

MeasureTime frame
Changes in cue based BOLD activation as measured by fMRI after 2 and 4 weeks of HDtDCS treatment.Timepoint: Changes in cue based BOLD activation as measured by fMRI after 2 and 4 weeks of HDtDCS treatment.—

Countries

India

Contacts

Public ContactDr Nishant Goyal

Central institute of psychiatry

nishantgoyal.cip@gov.in09431171162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026