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calculation and relation of biomarker with the success of apical periodontitis cases treated with three different intracanal medicaments.

Expression of MMP-8 and its correalation with long term clinical and radiological success of three intracanal medicaments used in cases with apical periodontitis- A randomised controlled trial.

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050992
Enrollment
70
Registered
2023-03-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Placement of Intracanal medicaments.: placement of intracanal medicament in the first visit of endodontic treatment which will be kept for 10 days. Intervention2: 1. Placement of Calciu

Sponsors

Dr Rajesh Kubde
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 and 50 years 2. Teeth with single root and single canal 3. Teeth with radiographic evidence of apical periodontitis (periapical index (PAI) >= 3, CBCT-PAI index >=2) 4. Tooth with no periodontitis

Exclusion criteria

Exclusion criteria: 1. Patients with any systemic diseases 2. Pregnant patients 3. Patients who had been taking antibiotics, non-steroidal anti-inflammatory drugs or corticosteroids 3 months prior to time of treatment 4. If the tooth had been previously accessed 5. Grossly decayed teeth where rubber dam isolation is difficult 6. Teeth with calcified canals 7. Patient periodontal pockets exceeding 4 mm depth

Design outcomes

Primary

MeasureTime frame
The patient will be assessed for pain at baseline in the clinic using visual analogue scale.Timepoint: 1 month, 3 months , 6 months, 12 months

Secondary

MeasureTime frame
Expression of MMP-8Timepoint: 1 month, 3 months , 6 months, 12 months

Countries

India

Contacts

Public ContactRajesh Kubde

VSPMs Dental College and research Centre, Nagpur

drrajeshkubde@gmail.com09881199669

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026