To study effect of a spray and an injection on heart rate and blood pressure when giving anesthesia

Comparison of efficacy of transmucosal nitroglycerinspray versus intravenous lignocaine for attenuation of haemodynamic responses to intubation

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050975

Enrollment

Registered

2023-03-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nitroglycerine spray: Nitroglycerin(400mcg/puff) two puffs will be sprayed soon after induction on oral cavity Control Intervention1: intravenous lignocaine: intravenous lignocaine 1.5

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing surgical procedures under general anaesthesiarequiring laryngoscopy and intubation Male and female patients Age >18 years ASA PS â?? I MP score I & II

Exclusion criteria

Exclusion criteria: Anticipated difficult airway Patients on rate controlling medications Duration of laryngoscopy >15sec, More than one attempt at intubation Use of bougie during intubation Risk of aspiration (full stomach, GERD, hiatus hernia, pregnancy) Emergency surgery H/o allergy to test drugs

Design outcomes

Primary

Measure	Time frame
To compare the change in heart rate at 1 minute following direct laryngoscopy and intubation from baseline, after transmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients.Timepoint: To compare the change in heart rate at 1 minute following direct laryngoscopy and intubation from baseline, after transmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients.	—

Measure

Time frame

To compare the change in heart rate at 1 minute following direct laryngoscopy and intubation from baseline, after transmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients.Timepoint: To compare the change in heart rate at 1 minute following direct laryngoscopy and intubation from baseline, after transmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients.

—

Secondary

Measure	Time frame
To compare changes in heart rate from baseline following induction, 3, 5, 10 and 15 minutes after direct laryngoscopy and intubation aftertransmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients. Changes in systolic, diastolic blood pressures and mean arterial pressure from baseline at all these time points,Timepoint: following induction, 3, 5, 10 and 15 minutes after direct laryngoscopy and intubation	—

Measure

Time frame

To compare changes in heart rate from baseline following induction, 3, 5, 10 and 15 minutes after direct laryngoscopy and intubation aftertransmucosal nitroglycerin spray versus intravenous lignocaine in surgical patients. Changes in systolic, diastolic blood pressures and mean arterial pressure from baseline at all these time points,Timepoint: following induction, 3, 5, 10 and 15 minutes after direct laryngoscopy and intubation

—

Countries

India

Contacts

Public ContactSherjin Dev S R

Amrita Institute of Medical Sciences

sunilrajan@aims.amrita.edu09447464652

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026