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BIO MARKERS OF COGNITIVE FUNCTIONING IN UNAFFECTED FIRST DEGREE RELATIVES OF DEMENTIA PROBANDS

NEUROIMAGING AND PERIPHERAL BIO MARKERS OF COGNITIVE FUNCTIONING IN UNAFFECTED FIRST DEGREE RELATIVES OF DEMENTIA PROBANDS:AN ENDOPHENOTYPE STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/03/050966
Enrollment
120
Registered
2023-03-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F028- Dementia in other diseases classified elsewhere

Interventions

None listed

Sponsors

Central Institute of Psychiatry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA (GROUP A) 1.First Degree Relatives of Dementia 2.Family History of Dementia in First degree relatives. 3.First degree relatives of subjects in patient group of either sex.  4.Aged between 18-50 years. 5.No comorbid psychiatric illness,substance use,psychosis,mood disorders. 6.Participants giving written informed consent. 7.Score of 3 or less on General Health Questionnaire 12 (GHQ 12) INCLUSION CRITERIA (GROUP B) Healthy Controls 1.Score of 3 or less on General Health Questionnaire-12 2.Matched with group A in respect to age, sex, education, and handedness. 3.No cognitive dysfunction according to Montreal Cognitive Assessment Test (MoCA) 4.Giving written informed consent. INCLUSION CRITERIA (GROUP C) Clinical Controls 1.Diagnosed with Dementia according to ICD 10, DCR (WHO, 1993). 2.Age >50 years of either sex 3.No diagnosable severe mental illness, Psychoses, Mood disorders, Substance Use Disorders. 4.Giving written informed consent/assent.

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA (GROUP A) 1.Underlying Organic disorders, Severe mental illness, substance use disorders, Psychosis, Mood disorders 2.Not giving written informed consent 3.Contraindications for MRI (Metallic Implants) EXCLUSION CRITERIA (GROUP B) 1.Current neurological or any comorbid major psychiatric disorders except nicotine or caffeine dependence. 2.History of substantial brain damage or any neurological procedures. 3.Presence of metallic implants. 4.Score of more than 3 on general health questionnaire GHQ-12. EXCLUSION CRITERIA (GROUP C) 1.Not willing to give informed consent. 2.Underlying severe mental illness, Psychoses, Mood disorders, Substance Use Disorders. 3.Presence of metallic implants. 4.Family History of Dementia  5.All forms of Secondary Dementias

Design outcomes

Primary

MeasureTime frame
Resting Functional MRI Blood Oxygenation Level Dependent Activation. Peripheral Biomarkers-Plasma Glial Fibrillary Acidic Protein and Salivary A beta 42. Cognitive Function as assessed by Addenbrookes Cognitive Examination III.Timepoint: One Time Assessment—

Secondary

MeasureTime frame
Resting Functional MRI Blood Oxygenation Level Dependent Activation. Peripheral Biomarkers-Plasma Glial Fibrillary Acidic Protein and Salivary A beta 42. Cognitive Function as assessed by Addenbrookes Cognitive Examination III.Timepoint: One Time Assessment—

Countries

India

Contacts

Public ContactDr Nishant Goyal

Central Institute of Psychiatry

nishantgoyal.cip@gov.in09431171162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026