It is a study done on patients undergoing general anaesthesia to study effect of precurarisation with succinylcholine on succinylcholine induced fasciculations and myalgia. The study is done to assess the efficacy of cisatracurium,rocuronium and placebo.

"A study to compare the effect of cisatracurium, rocuronium and placebo pretreatment on succinylcholine induced fasciculations and myalgia"

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050956

Enrollment

150

Registered

2023-03-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: M958- Other specified acquired deformities of musculoskeletal system

Interventions

Intervention1: nil: nil Control Intervention1: Group 1 - Cisatracurium: Cisatracurium is an intermediate acting nondepolarising skeletal muscle relaxant which blocks nicotinic cholinergic receptors. C

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective surgery under general anesthesia 2.Patients age between 18-60 years 3.Patients who fulfill American Society of Anesthesiology category I and II

Exclusion criteria

Exclusion criteria: 1.Cardiovascular, pulmonary or metabolic diseases 2.Morbid obesity 3.Neuromuscular disease 4.Anticipated airway difficulties 5.Intraocular hypertension 6.Malignant hyperthermia 7.Caesarean section

Design outcomes

Primary

Measure	Time frame
1.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing succinylcholine induced fasciculations. 2.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing postoperative myalgia in post-anesthesia care unit(PACU)Timepoint: 1.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing succinylcholine induced fasciculations at baseline. 2.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing postoperative myalgia in post-anesthesia care unit(PACU) for 2 hours.	—

Measure

Time frame

1.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing succinylcholine induced fasciculations. 2.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing postoperative myalgia in post-anesthesia care unit(PACU)Timepoint: 1.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing succinylcholine induced fasciculations at baseline. 2.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing postoperative myalgia in post-anesthesia care unit(PACU) for 2 hours.

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Secondary

Measure	Time frame
1.Study the efficacy of cisatracurium and rocuronium pretreatment in preventing postoperative myalgia at 24hoursTimepoint: From 2 hours post-operatively till 24hours post-operatively.	—

Countries

India

Contacts

Public ContactDr Manjushree P Babladi

Mahadevappa Rampure medical college

dr.gurupatil@gmail.com9481002895

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026