A study to compare two different methods of strengthening the cornea in a disease called Keratoconus in children

A Comaparitive study of Standard versus Accelerated protocols of Collagen cross linking in the treatment of Pediatric Keratoconus-A randomised controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050925

Enrollment

Registered

2023-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H186- Keratoconus

Interventions

Intervention1: Corneal collagen cross-linking: Study Participants with keratoconus are subjected to two different protocols of corneal collagen cross-linking the safety of which has been established i

Eligibility

Inclusion criteria

Inclusion criteria: 1)All patients in the above age group with clinically and topgraphically diagnosed keratoconus

Exclusion criteria

Exclusion criteria: 1) Patients not giving informed consent 2) Corneal thinnest local less than 400 micron 3) Post lasik ectasia 4) Traumatic ectasia 5) Previous ocular surgery

Design outcomes

Primary

Measure	Time frame
1)Difference in Kmax at the end of three years in the two protocols 2) Difference in corneal thickness measurements at the end of three years in the two protocolsTimepoint: At baseline followed by 1, 3,6,12,18,24,30 and 36 months	—

Secondary

Measure	Time frame
1)Visual outcome in terms of Logmar 2) Endothelial cell density changes in the two protocolsTimepoint: 3 years	—

Countries

India

Contacts

Public ContactSwetha Mallagundla

MINTO OPHTHALMIC HOSPITAL,BANGALORE MEDICAL COLLEGE AND RESEARCH INSTITUTE

drmswetha@gmail.com7348959926

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026