Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sevoflurane: Sevoflurane based anaesthesia maintenance regimen.
Anaesthesia maintenace dose: Sevoflurane inhaled 1 MAC titrated to anesthesia depth bispectral index (BIS) score of 40 -
Sponsors
Markose L Paret
SCTIMST
Eligibility
Inclusion criteria
Inclusion criteria: All adults above 18 years of age, in sinus rhythm, admitted with severe aortic stenosis with good LV function (Left ventricular ejection fraction more than or equal to 50%) for elective aortic valve replacement surgery will be included in the study
Exclusion criteria
Exclusion criteria: 1. Emergency surgeries 2. Redo surgeries 3. Patients not willing to participate in study 4. More than mild AR, MR or TR 5. Patients with coronary artery disease defined by lumen stenosis more than or equal to 50% in atleast one of major epicardial coronaries on coronary angiogram. 6. Patients receiving preoperative inotropes 7. Patients with poor echo differentiation of endocardial borders 8. Contraindication to TEE probe placement like esophageal strictures, esophageal varices, esophageal tumours, gastric ulcer, previous esophagectomy, esophageal diverticulum, tracheoesophageal fistula, previous bariatric surgery, hiatus hernia, large descending thoracic aortic aneurysm, unilateral vocal cord paralysis, esophageal varices, post-radiation therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in global longitudinal and global circumferential strain after aortic valve replacement in patients of severe aortic stenosis with good left ventricular ejection fraction 2. Compare effects of sevoflurane and propofol anaesthesia on changes in global longitudinal and circumferential strain after aortic valve replacement in patients of severe aortic stenosis with good left ventricular ejection fraction. Timepoint: 1. Strain echocardiography before aortic valve replacement in intraoperative period. 2. Strain echocardiography after aortic valve replacement in intraoperative period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assess preoperative global longitudinal and circumferential strains in patients with severe aortic stenosis and good left ventricular ejection fraction. 2. To study risk factors associated with preoperative changes in global longitudinal and circumferential strain in patients with severe aortic stenosis and good left ventricular ejection fraction. Timepoint: 1.Risk factor evaluation during preoperative anaesthesia check up. 2. Strain echocardiography before aortic valve replacement in intra operative period. 3.Strain echocardiography after aortic valve replacement in intraoperative period. | — |
Countries
India
Contacts
Public ContactMarkose L Paret
SCTIMST
Outcome results
None listed