effectiveness of tranexemic acid in reducing blood loss in vaginal hystrectomy

Assesing the Efficiency of Prophylactic use of local Tranexemic acid during vaginal Hystrectomy to reduce Intraoperative blood loss-A Double Blind Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050830

Enrollment

164

Registered

2023-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N996- Intraoperative hemorrhage and hematoma of a genitourinary system organ or structure complicating a procedure Health Condition 2: N996- Intraoperative hemorrhage and hematoma of a genitourinary system organ or structure complicating a procedure Health Condition 3: O- Medical and Surgical

Interventions

Intervention1: Tranexemic acid: Tranexamic acid (TXA) is an antifibrinolytic agent that has shown to effectively reduce bleeding complications within other surgical procedures.This study is therefore

Eligibility

Inclusion criteria

Inclusion criteria: All females scheduled for benign vaginal hystrectomy

Exclusion criteria

Exclusion criteria: Allergic to tranexemic acid, history of seizures,history of venous or arterial thromboembolism or active thromboembolic disease, severe renal impairment

Design outcomes

Primary

Measure	Time frame
To assess and compare the intraoperative estimation of blood loss (EBL) in Intervention group (Tranexemic acid) and Control group (saline)Timepoint: intraopertaively and 24 hours post procedure	—

Secondary

Measure	Time frame
To analyse the need of intraoperative intravenous (IV) TXA (to be given only if blood loss is more than 500 ml),To identify the change in haemoglobin level /Haematocrit from preoperatively to 24 hours postoperation,To look for the requirement of blood transfusion during primary hospitalization,To observe the duration of surgery Timepoint: to assess duration of surgery compare preop and 24 hours post op Hemoglobin and hematocrit fall	—

Measure

Time frame

To analyse the need of intraoperative intravenous (IV) TXA (to be given only if blood loss is more than 500 ml),To identify the change in haemoglobin level /Haematocrit from preoperatively to 24 hours postoperation,To look for the requirement of blood transfusion during primary hospitalization,To observe the duration of surgery Timepoint: to assess duration of surgery compare preop and 24 hours post op Hemoglobin and hematocrit fall

—

Countries

India

Contacts

Public ContactAnshivi Raje

AIIMS Jodhpur

Meenakshigothwal@gmail.com9212126860

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026