Health Condition 1: P369- Bacterial sepsis of newborn, unspecified Health Condition 2: P351- Congenital cytomegalovirus infection Health Condition 3: P352- Congenital herpesviral [herpes simplex] infection Health Condition 4: P379- Congenital infectious or parasiticdisease, unspecified Health Condition 5: P350- Congenital rubella syndrome Health Condition 6: P371- Congenital toxoplasmosis Health Condition 7: P359- Congenital viral disease, unspecified Health Condition 8: P353- Congenital viral h
Conditions
Interventions
None listed
Sponsors
Department of Health Research
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: Stillbirth/ Intrauterine death Premature rupture of membrane (PROM) Preterm delivery Early onset Foetal growth restriction (FGR) Unexplained early Oligoamnios Uteroplacental insufficiency as evidenced by abnormal Dopplerâ??s (early onset) CNS findings Ventriculomegaly Intracranial calcification Echogenic Bowel loops Third-space fluid collections Pleural effusion Hydrops fetalis Hepatosplenomegaly Fetal anaemia Calcification in liver
Exclusion criteria
Exclusion criteria: Pregnant woman with a previously established genetic abnormality. Non-consent individuals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Find prevalence of pathogens causing congenital infections and their clinical outcomes List of rare and common pathogens and their outcome in terms of fetal death or anomalies The finding of epidemiological, demographical and clinical, laboratory, and biomarkers associated with congenital infection and disease progressionTimepoint: 32 weeks in case of pre-partum 12 weeks in case of post-partum | — |
Secondary
| Measure | Time frame |
|---|---|
| Obtained data will be useful in the policy-making in future Improved clinical suspicion among physicians leading to better patient outcomes Information on sequelae of congenital infection and comparative analysis of sequelae upon infection of different pathogens Derive mitigation strategy for congenital infectionsTimepoint: 32 weeks in case of pre-partum 12 weeks in case of post-partum | — |
Countries
India
Contacts
Public ContactDr Chiranjay Mukhopadhyay
Manipal Institute of Virology
Outcome results
None listed