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Effect of deep magnetic stimulation on brain neural connection in schizophrenia

Effect of deep TMS on resting state functional connectivity of Default Mode Network and its clinical correlates in schizophrenia patients with prominent negative symptoms - SOCODMN

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050780
Enrollment
50
Registered
2023-03-17
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F20- Schizophrenia

Interventions

Intervention1: Transcranial Magnetic Stimulation: Deep Transcranial magnetic stimulation delivered through H7 coil. 7. Patient will then be divided into 2 arms. First arm will receive 20 sessions of i

Sponsors

IndiaAlliance,DBT wellcome
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients with diagnosis of schizophrenia as per DMS 5 and prominent negative symptoms with a score of 3 or more on each domain of affective flattening, alogia, avolition-apathy and anhedonia-asociality in Scale for Assessment of Negative Symptoms (SANS) 2 Stable dose of oral antipsychotics (defined as 3 Age of 18 â?? 60 years 4 Both male and female gender 5 Written informed consent from the patient

Exclusion criteria

Exclusion criteria: 1 Psychiatric emergency necessitating parenteral rescue medications or electroconvulsive therapy 2 Pregnancy or postpartum state 3 Substance use disorder in last 6 months 4 Co-morbid neurological or medical disease that can affect the brain structure or function 5 Any contraindication for Magnetic Resonance Imaging 6 Any contraindication for Transcranial Magnetic Stimulation 7 Clinically determined visual or hearing impairment

Design outcomes

Primary

MeasureTime frame
To examine the effect of deep TMS using H7 coil on resting state functional connectivity of default mode network in schizophrenia patients with prominent negative symptomsTimepoint: Assesments at baseline, immediately post treatment—

Secondary

MeasureTime frame
To examine association between change in resting state functional connectivity of DMN with change in measures of social cognition, general cognition and insight into illness To examine the effect of treatment on total negative symptom score in the patients To do a mediation analysis to assess the effect of DMN resting state functional connectivity on negative symptoms through changes in social cognition, general cognition and insight into illness. Timepoint: Assessments at baseline, Immediately post treatment and 3 months after treatment—

Countries

India

Contacts

Public ContactDr Manul Das

Central Institute of psychiatry

psynishant@gmail.com8075154073

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026