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To study if application of different levels of pressures at the end of breathing has any effects on pressures I the brain which can reflect as change in the pressure of nerve of the eye which can be studied with the help of ultrasonography

To study the Effects of two levels of Positive End-Expiratory Pressure (PEEP) by using Optic Nerve Sheath Diameter (ONSD) as a surrogate marker of Intracranial Pressures (ICP) in patients undergoing Laparoscopic cholecystectomy procedures: A Prospective Interventional Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050747
Enrollment
72
Registered
2023-03-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: PEEP 10 cm: Calculated values of ONSD at different levels of PEEP (5cm of H2O vs 10 cm of H2O) in patients undergoing laparoscopic cholecystectomy will be analysed and compared, Relatio

Sponsors

GSMC KEMH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age >18years ASA I andII Electivesurgery Undergoing General Anaesthesia for alaparoscopic cholecystectomy procedure

Exclusion criteria

Exclusion criteria: Patients’refusal Emergencysurgery Patients with neurological deficit Patients with ophthalmologic conditions affecting probe placement (e.g. Proptosis, exophthalmos, eye trauma 5) COPD 6) Hypo-hyperthyroid patients with ophthalmologic symptoms.

Design outcomes

Primary

MeasureTime frame
To compare the effects of different values of PEEP (5cm H2O) vs (10cm H2O) on intracranial pressures (ICP) with ONSD as a surrogate marker in laparoscopic surgeriesTimepoint: 3 minutes after intubation, after abdominal insufflation at 5mins, 15mins, 30mins, after specimen out and 5 mins after de-sufflation.—

Secondary

MeasureTime frame
Compare the effects of high PEEP on haemodynamic parameters and ventilation mechanics.Timepoint: 3 minutes after intubation, after abdominal insufflation at 5mins, 15mins, 30mins, after specimen out and 5 mins after de-sufflation.—

Countries

India

Contacts

Public ContactDHANASHRI RAMESH KARKHANIS

GSMC KEMH

DRKARKHANIS91@GMAIL.COM9820714864

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026