Health Condition 1: D691- Qualitative platelet defects
Conditions
Interventions
Intervention1: Group 1 - Fresh platelets
Group 2 - day 4-5 platelets: Group 1- Patients will be transfused platelet concentrates less than or equal to 3 days
Group 2- Patients will be transfused pla
Sponsors
GMCH Sector 32
Eligibility
Inclusion criteria
Inclusion criteria: Patients admitted to multidisciplinary ICU and requiring platelet transfusion. Age more than 18 years. Expected duration of ICU stay more than 24 hours. No platelet transfusion within 24 hours prior to ICU admission.
Exclusion criteria
Exclusion criteria: Patients with active bleeding or known bleeding disorder. Patients receiving out of group ABO compatible platelet transfusion. Patients receiving less than adult platelet dose. Patients with RhD negative blood groups. Patients with sepsis on admission. Patients with previous platelet transfusion within 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corrected count increment and percentage platelet recovery in both the study arms Timepoint: Post transfusion platelet count will be measured at 10 minutes to 1 hour and 18-24 hours after transfusion of at least four random donor platelet concentrates or one single donor platelet concentrate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in ICU, clinical bleeding WHO grade 2 or more, need for red cell transfusion, incidence of infections, adverse transfusion reactions and mortality.Timepoint: Length of stay in ICU, clinical bleeding WHO grade 2 or more, need for red cell transfusion, incidence of infections, adverse transfusion reactions and mortality. | — |
Countries
India
Contacts
Public ContactPARAMJIT KAUR
Government Medical College and Hospital, Chandigarh
Outcome results
None listed